Bactrim®
Trimethoprim/sulfamethoxazole
oral suspension, oral tablet
Indication
Treatment of preseptal cellulitis
Mechanism of Action
Inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid, blocking the production of tetrahydrofolic acid
Available Quantities
250mg, 500mg tablets; 100, 200ml Bottles (250mg per 5ml)
Dosage/Instructions
Children: 8 to 12 mg/kg/day trimethoprim with 40 to 60 mg/kg/day sulfamethoxazole p.o. in two divided doses. Adults: 160 to 320 mg trimethoprim with 800 to 1,600 mg sulfamethoxazole p.o. b.i.d.
Pregnancy & Nursing
No evidence of teratogenicity in rat studies at normal human dose
Pediatric Use
≥2 months
Contraindications, side effects, etc.
Contraindications: Known hypersensitivity to trimethoprim or sulfonamides, severe renal or liver disease, megaloblastic anemia due to folate deficiency.
Warnings/Precautions: Caution in patients with G6PD deficiency, severe allergies, asthma, or thyroid dysfunction. Avoid in late pregnancy and breastfeeding.
Common Side Effects: Nausea, vomiting, rash, hyperkalemia, and less commonly, severe skin reactions (e.g., Stevens-Johnson syndrome), hematological abnormalities, and renal impairment.
