monofixation syndrome
Also called MFS, microtropia, microstrabismus, monofixational phoria, Parks monofixation syndrome
A state of binocular vision in which one fovea is suppressed during binocular viewing while peripheral fusion, fusional vergence amplitudes and gross stereopsis are kept. It can exist with or without a measurable deviation of the eyes1,2. A suppression scotoma about 2.5 to 3 degrees across removes the central image of one eye, and the periphery of the retina continues to fuse and holds the eyes nearly straight1.
The syndrome is often treated as a synonym for microtropia, but strictly it also includes patients with straight eyes and a foveal scotoma, so microtropia is its commonest form rather than its definition1,2,3. It should be suspected when acuity in one eye is 20/25 to 20/40, stereoacuity is 30 to 80 seconds of arc and the cover test shows little or nothing; the 4 prism diopter base-out test confirms the central scotoma4.
More detail
It differs from bifoveal fusion, because fine stereopsis is absent1. The alternate cover test often reveals more than the cover-uncover test2. It is the usual best outcome after surgery for infantile esotropia and the reason the angle stays stable afterwards1.
Sources (4)
- Yanoff and Duker, Ophthalmology (2023), ch. 11
- von Noorden and Campos, Binocular Vision and Ocular Motility, ch. 16
- Kanski, Clinical Ophthalmology (2024), ch. 18
- Carlson and Kurtz, Clinical Procedures for Ocular Examination, ch. 4
Reviewed October 2026
Related terms
Nearby in the glossary
- medial rectus
- meridional amblyopia
- microtropia
- monofixation syndrome
- motor fusion (fusional reserves)
- myectomy