Cosopt PF (Dorzolamide 2% / Timolol 0.5%)

Warnings & Precautions

Systemic beta-blockade: Timolol is absorbed systemically from topical dosing, so reactions attributable to systemic beta-blockers can occur. Severe respiratory reactions including death due to bronchospasm in patients with asthma, and rarely death associated with cardiac failure, have been reported after systemic or ophthalmic timolol.
Cardiac failure: Beta-blockade may precipitate more severe failure where sympathetic stimulation supports the circulation, and in patients with no history of cardiac failure, continued myocardial depression over time can itself lead to failure. Discontinue at the first sign or symptom.
Sulfonamide hypersensitivity: Dorzolamide is a sulfonamide that is absorbed systemically despite topical dosing, so the reactions attributable to sulfonamides can occur, rarely fatal, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Sensitization may recur when a sulfonamide is readministered by any route; discontinue if a serious reaction or hypersensitivity occurs.
Obstructive pulmonary disease: Patients with mild or moderate COPD or bronchospastic disease should in general not receive beta-blockers; asthma, a history of asthma, and severe COPD are contraindications.
Increased reactivity to allergens: Patients with a history of atopy or of severe anaphylaxis may be more reactive to allergen challenge while on a beta-blocker and may be unresponsive to the usual doses of epinephrine.
Potentiation of muscle weakness: Beta-blockade can potentiate myasthenic symptoms such as diplopia, ptosis, and generalized weakness, and timolol has rarely increased weakness in myasthenia gravis.
Masking of hypoglycemic symptoms: Beta-blockers may mask the signs and symptoms of acute hypoglycemia; caution in spontaneous hypoglycemia and in diabetic patients on insulin or oral hypoglycemics.
Masking of thyrotoxicosis: Beta-blockers may mask tachycardia and other signs of hyperthyroidism, and abrupt withdrawal may precipitate thyroid storm.

Cosopt PF (Dorzolamide 2% / Timolol 0.5%) | EyeKnow O.D.