CYKLX is an amide local anesthetic indicated for ocular surface anesthesia prior to ocular procedures and/or intraocular injections in adults and pediatric patients.
Contraindications
CYKLX is contraindicated in patients with known hypersensitivity to any component of this preparation.
Available Forms
8%, 0.4 mL single-dose vials
Mechanism of Action
Articaine hydrochloride is an amide local anesthetic. Local anesthetics block the generation and conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of the affected nerve fibers.
Dosage
The recommended dose of CYKLX is 2 drops applied 30 seconds apart to the ocular surface.
Warnings & Precautions
For Topical Ophthalmic Use: CYKLX is not for injection or intraocular administration.
Corneal Injury Due to Insensitivity: Patients should not touch the eye for at least 10 to 20 minutes after using CYKLX as accidental injuries can occur due to insensitivity of the eye.
Corneal Opacification: Prolonged use of topical ocular anesthetics may produce permanent corneal opacification and ulceration with accompanying visual loss.
Risk of Contamination: Do not touch the dropper tip to the eye, eyelids, or any other surface as this may contaminate the solution.
Common Side Effects
The most common adverse reaction with CYKLX was instillation site pain reported in 24.5% (70/286) of subjects, compared to 6.9% (14/203) of subjects in the placebo group.
Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women with CYKLX to inform a drug associated risk.
Lactation: There is no information regarding the presence of CYKLX or its metabolites in human or animal milk, the effects on the breastfed infant, or the effects on milk production to inform risk of CYKLX to an infant during lactation.
Pediatric Use
The safety and effectiveness of CYKLX for ocular surface anesthesia prior to ocular procedures and/or intraocular injections have been established in pediatric patients.
GoodRx
Indication
Available Forms
Mechanism of Action
Dosage
Pregnancy & Lactation
Pediatric Use