Homatropine
GoodRxHomatropine HBr 2%, 5% · ophthalmic solution
Mydriatics/Cycloplegics
Approved uses
Cycloplegic refraction
1 or 2 drops of 5% topically; may be repeated in 5 to 10 minutes if necessary. Heavily pigmented irides may require larger doses.
Uveitis and other inflammatory conditions of the uveal tract
1 or 2 drops of 5% topically up to every 3 to 4 hours.
Contraindications
- Primary glaucoma or a tendency toward glaucoma, such as a narrow anterior chamber angle
- Hypersensitivity to any component
Available FormsOphthalmic solution, 5%, 5 mL plastic bottle
Mechanism of ActionAnticholinergic; blocks the response of the iris sphincter and the accommodative muscle of the ciliary body to cholinergic stimulation, producing mydriasis and paralysis of accommodation. The label characterizes the resulting mydriasis and cycloplegia as moderately long-acting.
Warnings & Precautions
- Route restriction: Topical ophthalmic use only; not for injection.
- Keratoconus: May produce a fixed dilated pupil; weigh risk against benefit.
- Increased susceptibility: Down syndrome, children with brain damage, and the elderly; extreme caution in infants and small children.
- Systemic anticholinergic poisoning: Excessive use in pediatric patients, or in those with a history of susceptibility to belladonna alkaloids, may produce systemic symptoms.
- Systemic absorption: Compress the lacrimal sac by digital pressure for 2 to 3 minutes after instillation.
- Amblyopia in early infancy: The cycloplegia produced is possibly associated with development of amblyopia, which is why the drug is not used during the first 3 months of life.
Common Side Effects
- Ocular: Transient stinging and burning; eye irritation not present before therapy; increased sensitivity of the eyes to light.
- Ocular, prolonged use: Local irritation with follicular conjunctivitis, vascular congestion, edema, exudates, and eczematoid dermatitis.
- Systemic: Thirst or dryness of mouth.
Pregnancy & LactationPregnancy: Category C. Animal reproduction studies have not been conducted; give only if clearly needed.
Lactation: Excretion in human milk unknown; use caution.
Pediatric UseNot for use during the first 3 months of life.