Approved uses
Primary herpetic keratoconjunctivitis and recurrent epithelial keratitis, HSV types 1 and 2
One drop onto the cornea of the affected eye every 2 hours while awake, to a maximum of nine drops daily, until the ulcer re-epithelializes; then one drop every 4 hours for a further 7 days
The 21-day ceiling matters: beyond it the corneal toxicity outweighs the antiviral effect
Contraindications
Trifluridine Ophthalmic Solution is contraindicated for patients who develop hypersensitivity reactions or chemical intolerance to trifluridine.
Available FormsTrifluridine ophthalmic solution 1%, 7.5 mL fill in a plastic bottle with a dropper tip.
Mechanism of ActionTrifluridine interferes with DNA synthesis in cultured mammalian cells. However, its antiviral mechanism of action is not completely known.
Warnings & Precautions
- The recommended dose and frequency should not be exceeded.
- Mild local irritation of the conjunctiva and cornea may occur on instillation.
Pregnancy & Lactation
Pediatric Use