covariation
Covariation is the ability to maintain harmonious anomalous retinal correspondence despite changes in the objective angle of strabismus.1 As the objective angle changes, the angle of anomaly changes with it.2
In harmonious anomalous correspondence the angle of anomaly equals the objective angle, the subjective angle is zero, and the sensory adaptation is complete.3 Covariation keeps that match as the deviation changes.1 In intermittent strabismus the patient has normal retinal correspondence with the visual axes straight and harmonious anomalous correspondence with the eyes deviated. The change between the two can be sudden or gradual.2 Covariation is likely to place extra neural demands on the visual system, so constant strabismus is more likely than intermittent or variable strabismus to develop harmonious anomalous correspondence.2
During treatment of the motor deviation, a patient with harmonious anomalous correspondence may show covariation without changing vergence.4 The practitioner should confirm normal correspondence with the cover test and watch for appropriate vergence movements.4
More detail
On the major amblyoscope, normal correspondence is present if the patient sees the targets superimposed with the arms set at the objective angle. Harmonious anomalous correspondence is present if the targets superimpose with the arms set at zero. Unharmonious anomalous correspondence is present if the angle of anomaly is smaller than the objective angle.3
Sources (11)
- Pickwell's Binocular Vision Anomalies, Appendices (glossary)
- Pickwell's Binocular Vision Anomalies, ch. 12
- von Noorden and Campos, Binocular Vision and Ocular Motility, ch. 13
- Pickwell's Binocular Vision Anomalies, ch. 14
- Noorden, G. K. V., & Campos, E. C. (2002). Binocular vision and ocular motility: Theory and management of strabismus. Mosby.
- Kushner, B. J. (2017). Strabismus. In W. Tasman & E. A. Jaeger (Eds.), Duane's Ophthalmology (2017 ed.). Lippincott Williams & Wilkins.
- PubMed Central: PMC10527918
- PubMed: 13960524
- PubMed: 1269367
- PubMed Central: PMC7354857
- PubMed: 13833807
Reviewed October 2026