Bacitracin Ointment (bacitracin 500 units/gram)

Approved uses

Superficial bacterial infection of the conjunctiva or cornea

Apply into the conjunctival sac 1 to 3 times daily.

OFF-LABELNot in the FDA label for this product

Anterior blepharitis (lid margin application)

Remove all scales and crusts, then spread uniformly over the lid margins, 1 to 3 times daily.

Cochrane · class-level only

Blepharitis appears only in this label's Dosage and Administration section; Indications and Usage is limited to conjunctiva and cornea, so lid-margin use sits outside the stated indication. No product-specific trial exists. A Cochrane systematic review and meta-analysis of 34 trials in 2,169 participants with chronic blepharitis found topical antibiotics as a class gave some symptomatic relief and eradicated lid margin bacteria in anterior blepharitis, but its overall conclusion was that there is no strong evidence that any treatment cures chronic blepharitis; that finding is class-level and was not measured on this product.

Dose: FDA label, Dosage and Administration. Class evidence: Lindsley K, Matsumura S, Hatef E, Akpek EK. Interventions for chronic blepharitis. Cochrane Database Syst Rev. 2012;2012(5):CD005556 (Systematic Review and Meta-Analysis per PubMed).

Contraindications

History of hypersensitivity to bacitracin.