Approved uses
Bacterial corneal ulcer
2 drops q15min x 6 hours, then q30min for the rest of day 1; 2 drops hourly on day 2; 2 drops q4h on days 3 to 14, extended past day 14 if not re-epithelialized.
Cures as often as fortified tobramycin-cefazolin, with significantly less discomfort.
Bacterial conjunctivitis
1 or 2 drops in the conjunctival sac q2h while awake x 2 days, then 1 or 2 drops q4h while awake x 5 days.
Eradicated bacteria in 90% of children by day 7, on par with tobramycin.
Contraindications
- Hypersensitivity to ciprofloxacin or any other component of this product.
- A history of hypersensitivity to other quinolones may also contraindicate use.
Available FormsOphthalmic solution, 2.5 mL, 5 mL, 10 mL bottles, 0.3% (3 mg ciprofloxacin base per mL)
Mechanism of ActionFluoroquinolone; bactericidal through interference with DNA gyrase, the enzyme needed for synthesis of bacterial DNA, with additional inhibition of topoisomerase IV, the primary quinolone target in susceptible Staphylococcus aureus. Broad gram-negative and gram-positive ocular coverage including Pseudomonas aeruginosa, with peak plasma concentrations under 5 ng/mL on the labeled conjunctivitis schedule.
Pregnancy & Lactation
Pediatric Use