1 to 2 drops up to hourly by day and every 2 hours overnight initially, reduced to 1 drop every 4 hours on response, then 1 drop TID to QID
Contraindications
Acute superficial herpes simplex keratitis.
Fungal diseases of ocular structures.
Acute infectious stages of vaccinia, varicella, and most other viral diseases of the cornea and conjunctiva.
Tuberculosis of the eye.
Hypersensitivity to a component of this medication.
Always contraindicated after uncomplicated removal of a superficial corneal foreign body.
Available Forms
1% solution (prednisolone sodium phosphate 10 mg/mL, equivalent to 9.1 mg/mL prednisolone phosphate), 10 mL bottle
Mechanism of Action
Glucocorticoid, supplied as the water-soluble phosphate ester in solution: inhibits the inflammatory response to inciting agents of mechanical, chemical, or immunological nature, and the label states that no generally accepted explanation of this property has been advanced. The class mechanism is induction of lipocortins, which inhibit phospholipase A2 and so block release of arachidonic acid and the prostaglandins and leukotrienes downstream of it.
Warnings & Precautions
Route restriction: Not for injection into the eye, topical use only.
Herpes simplex stromal keratitis: Steroid use where the stroma is involved requires great caution, and frequent slit lamp microscopy is mandatory.
IOP elevation and glaucoma: Prolonged use may raise IOP and produce glaucoma, optic nerve damage, and defects in visual acuity and visual fields; check IOP frequently.
Posterior subcapsular cataract: Prolonged use may produce it.
Secondary ocular infection: Prolonged use may aid establishment of secondary ocular infection from pathogens liberated from ocular tissues, and acute purulent untreated infection of the eye may be masked or its activity enhanced.
Corneal or scleral perforation: In diseases causing thinning of the cornea or sclera, perforation has occurred with topical steroids.
Viral, bacterial, and fungal keratitis: All three may be exacerbated by steroid application; suspect fungal invasion in any persistent corneal ulceration where a steroid has been used or is in use.
Mustard gas keratitis and Sjogren keratoconjunctivitis: Not effective in either.
Persistent irritation: Discontinue if irritation persists or develops.
Common Side Effects
Ocular, serious: Glaucoma with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection from pathogens including herpes simplex and fungi, and perforation of the globe.
Ocular, rare: Stinging or burning on instillation; filtering blebs when topical steroids have been used following cataract surgery.
Frequency data: This label gives no incidence figures for any adverse reaction, only the qualifier 'rarely' on the two items above.
Pregnancy & Lactation
Pregnancy: Animal reproductive studies have not been conducted. Whether the drug can cause fetal harm or affect reproductive capacity is unknown, as is its effect on the later growth, development, and functional maturation of the child; give during pregnancy only if clearly needed.
Lactation: Whether the drug is excreted in human milk is unknown; because many drugs are, use with caution in a nursing woman.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Inflamase Forte (Prednisolone Sodium Phosphate 1.0%) | EyeKnow O.D.