Approved uses
Acute pain severe enough to require an opioid
1 tablet (7.5 mg/325 mg) every 4 to 6 hours as needed, at the lowest dose that gives adequate analgesia
Schedule II; the acetaminophen ceiling of 4,000 mg a day still applies across all products
Contraindications
This product should not be administered to patients who have previously exhibited hypersensitivity to hydrocodone or acetaminophen.
Available FormsHydrocodone bitartrate and acetaminophen tablets, 7.5 mg/325 mg and 10 mg/325 mg.
Mechanism of ActionHydrocodone is a semisynthetic opioid agonist that primarily acts on the mu-opioid receptors in the central nervous system, producing analgesia, respiratory depression, and sedation. Acetaminophen is a non-opioid, non-salicylate analgesic and antipyretic. It works by inhibiting the synthesis of prostaglandins in the central nervous system and peripherally blocking pain impulse generation, producing antipyresis from inhibition of the hypothalamic heat-regulating center
Warnings & Precautions
Pregnancy & Lactation
Pediatric Use