Neurontin®
GoodRxGabapentin · oral capsule
Analgesics
Approved uses
Postherpetic neuralgia
Day 1: a single 300 mg dose. Day 2: 600 mg/day in two doses. Day 3: 900 mg/day in three doses. Titrate as needed up to 1,800 mg/day
The reason this card matters in eye care: postherpetic neuralgia after herpes zoster ophthalmicus
Partial onset seizures, adjunctive therapy, age 12 and over
Start at 300 mg three times daily; may be titrated up to 600 mg three times daily
Contraindications
Gabapentin Oral Solution is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients. Known hypersensitivity to gabapentin or its ingredients.
Available FormsGabapentin 250 mg per 5 mL oral solution; capsules and tablets in 100, 300, 400, 600 and 800 mg.
Mechanism of ActionThe precise mechanism by which Gabapentin produces its analgesic and antiepileptic action are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that Gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
Warnings & Precautions
- Suicidal behaviour and ideation have been reported with antiepileptic drugs; monitor for the emergence or worsening of depression or unusual changes in mood.
- Somnolence, dizziness and ataxia are common and may impair driving; effects are additive with other CNS depressants.
- Respiratory depression can occur when combined with opioids or in pre-existing respiratory impairment.
- Drug reaction with eosinophilia and systemic symptoms (DRESS) and anaphylaxis have been reported.
- Do not discontinue abruptly; withdraw over at least one week.
Common Side Effects
The most common adverse reactions associated with the use of Gabapentin in adults, not seen at an equivalent frequency among placebo-treated patients, were dizziness, somnolence, and peripheral edema.
Pregnancy & LactationPregnancy: No adequate and well-controlled studies in pregnant women; gabapentin caused developmental toxicity in animals at clinically relevant exposures.
Lactation: Gabapentin is present in human milk; consider the mother's clinical need alongside any potential effect on the infant.
Pediatric UseSafety and effectiveness of gabapentin in the management of postherpetic neuralgia in pediatric patients have not been established. Safety and effectiveness as adjunctive therapy in the treatment of partial seizures in pediatric patients below the age of 3 years has not been established.