Mupirocin
GoodRxMupirocin 2% · topical cream
Antibiotic
Approved uses
Secondarily infected traumatic skin lesions caused by S. aureus or S. pyogenes
A small amount applied with a cotton swab or gauze to the affected area three times daily for 10 days
The label explicitly says not for ophthalmic use: this is a skin preparation, not a lid-margin or ocular one
Contraindications
Mupirocin cream is contraindicated in patients with known hypersensitivity to mupirocin or any of the excipients of mupirocin cream.
Available FormsMupirocin cream 2%, in 15 g and 30 g tubes.
Mechanism of ActionMupirocin is an RNA synthetase inhibitor antibacterial.
Warnings & Precautions
- Not for ophthalmic use, nor for intranasal use of the cream formulation.
- Severe allergic reactions, including anaphylaxis, urticaria and generalised rash, have been reported.
- Clostridioides difficile-associated diarrhoea has been reported with almost all antibacterials.
- If a sensitisation or severe local irritation occurs, stop and institute other therapy.
Common Side Effects
The most frequent adverse reactions (at least 1%) were headache, rash, and nausea.
Pregnancy & LactationPregnancy: Systemic absorption after topical use is minimal; available data are insufficient to identify a drug-associated risk.
Lactation: Minimal systemic absorption after topical use; do not apply to the breast until the infant has finished feeding.
Pediatric UseThe safety and effectiveness of mupirocin cream have been established in the age-groups 3 months to 16 years. Use of mupirocin cream in these age-groups is supported by evidence from adequate and well‑controlled trials of mupirocin cream in adults with additional data from 93 pediatric subjects studied as part of the pivotal.