Staining of the internal limiting membrane during vitreoretinal surgery
Injected into the BSS-filled vitreous cavity through a blunt cannula; staining takes a few seconds, then all excess dye is removed
Stains the ILM but not the epiretinal membrane or retina, which is what makes the peel possible
Contraindications
None.
Available Forms
0.5 mL of Brilliant Blue G ophthalmic solution 0.025% in a sterile pre-filled syringe.
Mechanism of Action
Brilliant Blue G has been shown to selectively stain the ILM, but not the epiretinal membrane nor the retina, making it easier to visualize the membrane for removal, although the exact mechanism of this selectivity has not been elucidated.
Warnings & Precautions
Excessive staining: remove excess dye from the eye immediately after staining.
Check that the syringe plunger moves smoothly before injecting; do not use the product if it does not.
Do not allow the cannula to contact the retina, and do not allow the dye to pass under the retina.
Common Side Effects
Adverse reactions that have been reported in procedures that included the use of Brilliant Blue G Ophthalmic Solution have often been associated with the surgical procedure. These complications include retinal (retinal break, tear, hemorrhage, and detachment) and cataracts. Adverse reactions that have been reported in procedures that included the use of TissueBlue 0.025% have often been associated with the surgical procedure.
Pregnancy & Lactation
Pregnancy: No available data on use in pregnant women; systemic absorption is expected to be negligible.
Lactation: No data; systemic absorption is expected to be negligible.
Pediatric Use
The safety and effectiveness of TissueBlue 0.025% in pediatric patients has not been established.
TissueBlue (Brilliant Blue G 0.025%) | EyeKnow O.D.
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Available Forms
Mechanism of Action
Pregnancy & Lactation
Pediatric Use