TissueBlue®
GoodRxBrilliant Blue G 0.025% · intraocular injection
Diagnostic Dye
Approved uses
Staining of the internal limiting membrane during vitreoretinal surgery
Injected into the BSS-filled vitreous cavity through a blunt cannula; staining takes a few seconds, then all excess dye is removed
Stains the ILM but not the epiretinal membrane or retina, which is what makes the peel possible
Contraindications
None.
Available Forms0.5 mL of Brilliant Blue G ophthalmic solution 0.025% in a sterile pre-filled syringe.
Mechanism of ActionBrilliant Blue G has been shown to selectively stain the ILM, but not the epiretinal membrane nor the retina, making it easier to visualize the membrane for removal, although the exact mechanism of this selectivity has not been elucidated.
Warnings & Precautions
- Excessive staining: remove excess dye from the eye immediately after staining.
- Check that the syringe plunger moves smoothly before injecting; do not use the product if it does not.
- Do not allow the cannula to contact the retina, and do not allow the dye to pass under the retina.
Common Side Effects
Adverse reactions that have been reported in procedures that included the use of Brilliant Blue G Ophthalmic Solution have often been associated with the surgical procedure. These complications include retinal (retinal break, tear, hemorrhage, and detachment) and cataracts. Adverse reactions that have been reported in procedures that included the use of TissueBlue 0.025% have often been associated with the surgical procedure.
Pregnancy & LactationPregnancy: No available data on use in pregnant women; systemic absorption is expected to be negligible.
Lactation: No data; systemic absorption is expected to be negligible.
Pediatric UseThe safety and effectiveness of TissueBlue 0.025% in pediatric patients has not been established.