Tobrex® Ointment

Tobramycin 0.3% · ophthalmic ointment

Antibiotic

• Intraocular injection: Not for injection into the eye; topical ophthalmic formulation only.
• Aminoglycoside hypersensitivity: Reactions range from local effects to generalized erythema, itching, urticaria, skin rash, anaphylaxis, anaphylactoid or bullous reactions; discontinue if sensitivity occurs.
• Aminoglycoside cross-sensitivity: Cross-sensitivity to other aminoglycoside antibiotics may occur; discontinue and institute appropriate therapy if hypersensitivity develops.
• Superinfection: Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi; start appropriate therapy if superinfection occurs.
• Corneal epithelial toxicity: Tobramycin solution was among the three most toxic of eight topical antibiotic solutions tested in a rabbit corneal wound-healing model; the ointment vehicle was not studied, so prolonged use over an epithelial defect warrants caution.
• Systemic aminoglycoside class effects: Neurotoxicity, ototoxicity and nephrotoxicity have occurred with systemic aminoglycoside therapy, which may also aggravate muscle weakness in neuromuscular disorders such as myasthenia gravis or Parkinson disease.
• Contact lens wear: Not advised while signs and symptoms of ocular infection are present.