aberrant regeneration

Aberrant regeneration is a possible sequela of an oculomotor nerve palsy, resulting in abnormal lid, pupillary, and ocular motility. It occurs when regenerating axons are misdirected to anomalous connections within the oculomotor nerve. Common signs include lid elevation on adduction (pseudo-Graefe’s sign) or infraduction, and pupillary constriction on adduction. The most frequent causes are trauma, tumors, and aneurysms. Onset typically appears within 6-12 months after the initial injury.