Calculators

Contacts

Drugs

Contact Lenses Medications Glossary Calculators Handouts Exam Prep

Disclaimer Privacy Policy Terms of Use Contact

Educational resource only — not medical advice. Independent study tool, not affiliated with or endorsed by the NBEO®. See our Disclaimer.

Medications›Dry Eye/OSD›Lacrisert

Lacrisert®

GoodRx

Hydroxypropyl Cellulose 5 mg · ophthalmic insert

Dry Eye/OSD, Injections & Implants

Approved uses

Moderate to severe dry eye syndrome, including keratoconjunctivitis sicca

One 5 mg insert in each eye once daily; some patients require twice daily.

Exposure keratitis, decreased corneal sensitivity, recurrent corneal erosions

One 5 mg insert in each eye once daily; some patients require twice daily.

Contraindications

Hypersensitivity to hydroxypropyl cellulose

Available Forms

5 mg insert, 60 unit doses per carton, two reusable applicators included

Mechanism of Action

Stabilizes and thickens the precorneal tear film and prolongs tear film breakup time, which is accelerated in dry eye states. Also lubricates and protects the ocular surface.

Warnings & Precautions

Corneal abrasion: Improper placement can abrade the cornea; seat the insert deep in the inferior cul-de-sac beneath the base of the tarsus.

Other Dry Eye/OSD, Injections & Implants drugs

Acetylcysteine
Actemra®
Avastin®
Beovu®
Botox®
Cequa®
Dextenza®
Durysta®

Browse all medications All Dry Eye/OSD drugs All Injections & Implants drugs

Transient blurred vision: Most common adverse event leading to discontinuation, 8.7% (45 of 520) in a 4-week open-label registry; caution with driving and hazardous machinery.

Expulsion from the fornix: Shallow conjunctival fornices predispose; eye rubbing, especially on awakening, can dislodge it.

Foreign body sensation: Misplacement into the interpalpebral fissure or at the tarsal plate level produces foreign body symptoms; recheck position and remove if symptoms persist.

Common Side Effects

Ocular: Transient blurring of vision, ocular discomfort or irritation, matting or stickiness of eyelashes, photophobia, eyelid edema, hyperemia; mild and transient in most instances.
Hypersensitivity: Reported; label gives no frequency.

Pregnancy & Lactation

Feeding of hydroxypropyl cellulose to rats at levels up to 5% of their diet produced no gross or histopathologic changes or other deleterious effects.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Lacrisert (Hydroxypropyl Cellulose 5 mg) | EyeKnow O.D.