Approved uses
Keratoconjunctivitis sicca (dry eye)
One drop BID in each eye, approximately 12 hours apart
Sign improvement on corneal staining begins at day 28 and builds through day 84, without symptom relief.
Contraindications
None.
Available Forms0.09% (0.9 mg/mL) preservative-free solution, 0.25 mL single-use vials, 60-vial box (6 pouches of 10) that must be dispensed intact
Mechanism of ActionCalcineurin inhibitor immunosuppressant; blocking calcineurin suppresses the T-cell cytokine signaling that drives ocular surface inflammation, and the label calls topical cyclosporine a partial immunomodulator whose exact ocular mechanism is not known. Supplied as a clear aqueous nanomicellar solution of cyclosporine 0.09%, and blood levels after BID dosing are at or below 0.2 ng/mL.
Warnings & Precautions
- Vial tip contamination: Contact between the vial tip and the eye or any other surface risks eye injury and contamination of the solution.
Pregnancy & Lactation
Pediatric Use