Ozurdex®
GoodRxDexamethasone 0.7 mg · intravitreal implant
Injections & Implants, Steroid
Approved uses
Macular edema following branch or central retinal vein occlusion
One 0.7 mg implant intravitreally under aseptic conditions
Duration of effect is roughly 3 to 6 months, so repeat treatment is usual
Non-infectious uveitis affecting the posterior segment
One 0.7 mg implant intravitreally
Diabetic macular edema
One 0.7 mg implant intravitreally
Contraindications
Ocular or periocular infections Glaucoma Torn or ruptured posterior lens capsule Hypersensitivity.
Available Forms0.7 mg dexamethasone intravitreal implant in a foil pouch with one single-use applicator.
Mechanism of ActionDexamethasone, a corticosteroid, has been shown to suppress inflammation by inhibiting multiple inflammatory cytokines resulting in decreased edema, fibrin deposition, capillary leakage and migration of inflammatory cells.
Warnings & Precautions
- Intravitreal injection carries a risk of endophthalmitis, eye inflammation, increased intraocular pressure and retinal detachment; monitor after injection.
- Corticosteroids may cause posterior subcapsular cataract, raised intraocular pressure and glaucoma, and may worsen an existing infection.
- The implant may migrate into the anterior chamber in eyes with an absent or torn posterior capsule.
- Do not use in active or suspected ocular or periocular infection.
Common Side Effects
the most common adverse reactions reported by 20-70% of patients were cataract, increased intraocular pressure and conjunctival hemorrhage.
Pregnancy & LactationPregnancy: No adequate and well-controlled studies in pregnant women. Topical ocular dexamethasone in mice and rabbits during organogenesis produced fetal harm.
Lactation: Systemically administered corticosteroids appear in human milk; the amount after an intravitreal implant is likely to be undetectable.
Pediatric UseSafety and effectiveness of OZURDEX in pediatric patients have not been established.