Xipere®
GoodRxTriamcinolone Acetonide 40 mg/mL · injectable suspension
Steroid, Injections & Implants
IndicationXIPERE ® is a corticosteroid indicated for the treatment of macular edema associated with uveitis.
Contraindications
Ocular or periocular infections Hypersensitivity to triamcinolone or any component of this product.
Available Forms40 mg/mL
Mechanism of ActionTriamcinolone acetonide is a synthetic glucocorticoid (glucocorticoids are often referred to as corticosteroids) with immunosuppressive and anti-inflammatory activity. The primary mechanism of action for triamcinolone acetonide is as a corticosteroid hormone receptor agonist.
DosageThe recommended dosage is 4 mg (0.1 mL) administered as a suprachoroidal injection.
Warnings & Precautions
- Potential Corticosteroid-Related Effects: Use of corticosteroids may produce cataracts, increased intraocular pressure, and glaucoma. Use of corticosteroids may enhance the establishment of secondary ocular infections due to bacteria, fungi, or viruses.
- Alterations in Endocrine Function: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing’s syndrome, and hyperglycemia can occur following administration of a corticosteroid. Monitor patients for these conditions with chronic use.
Common Side Effects
the most common adverse reactions reported by ≥ 10% of patients and at a rate greater than control included elevated intraocular pressure and eye pain.
Pregnancy & LactationPregnancy: There are no adequate and well-controlled studies with XIPERE ® in pregnant women to inform drug-associated risks. In animal reproductive studies from the published literature, topical ocular administration of corticosteroids has been shown to produce teratogenicity at clinically relevant doses.
Lactation: It is not known whether ocular administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk.
Pediatric UseSafety and effectiveness of XIPERE ® in pediatric patients have not been established.